Recent research publications

Review articles can be found here.

A full list of publications can be found on ORCID.


Parker J.L, Kato T, Kuteyi G, Sitsel O, Newstead S. (2023) Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nature Structural & Molecular Biology.

Loebel M, Salphati, S.P, El Omari K, Wagner A, Tucker S.J, Parker J.L, Newstead S. (2022) Structural basis for proton coupled cystine transport by cystinosin. Nature Communications.

Fiore A, Zeitler L, Russier M, Groß A, Hiller MK, Parker JL, Stier L, Köcher T, Newstead S, Murray PJ. (2022) Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling. Mol Cell.

Parker J.L, Deme J.C, Zhiyi Wu, Kuteyi G, Jiandong Huo, Raymond J. Owens, Biggin P.C, Lea S.M, Newstead S. (2021) Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. SciAdv

Parker J.L, Deme J.C, Kolokouris D, Kuteyi G, Biggin P.C, Lea S.M, Newstead S. (2021) Molecular basis for redox control by the human cystine/glutamate antiporter System xc. Nature Communications

Adams O, Deme J.C, Parker J.L, the CRyPTIC Consortium, Fowler P.W., Lea S.M, Newstead S. (2021) Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target. Structure.

Parker J.L, Deme J.C, Kuteyi G, Wu Z, Huo J, David Goldman I, Owens R.J, Biggin P.C, Lea S.M, Newstead S. (2021) Structural basis of antifolate recognition and transport by PCFT. Nature.

Gerondopoulos A, Bräuer P, Sobajima T, Wu Z, Parker JL, Biggin PC, Barr FA, Newstead S. (2021) A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval. Elife.

Wu Z, Newstead S, Biggin PC. (2020) The KDEL trafficking receptor exploits pH to tune the strength of an unusal short hydrogen bond. Sci Rep.

van Dijk FS, et al. (2020) Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2. Am J Hum Genet.

Zimmermann I, Egloff P, Hutter CAJ, Kuhn BT, Bräuer P, Newstead S, Dawson RJP, Geertsama ER, Seeger MA. (2020) Generation of synthetic nanobodies against delicate proteins. Nat Protoc.

Parker JL, Corey R, Stansfeld P, Newstead S. (2019) Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer. Nature Communications.

Zhiyi W, Alibay I, Newstead S, Biggin PC. (2019) Proton control transitions in an amino acid transporters. Biophysical Journal.

Bräuer P, Parker JL, Gerondopoulos A, Zimmermann I, Seeger MA, Barr FA, Newstead S. (2019) Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor. Science

Minhas GS, Newstead S. (2019) Structural basis for prodrug recognition by the SLC15 family of proton coupled peptide transporters. PNAS.

Minhas GS, Bawdon D, Herman R, Rudden M, Stone AP, James AG, Thomas GH, Newstead S. (2018) Structural basis of malodour precursor transport in the human axillaeLIFE

McIlwain BC, Newstead S, Stockbridge RB. (2018) Cork-in-Bottle Occlusion of Fluoride Ion Channels by Crystallization Chaperones. Structure

Jungnickel, EJK, Parker JL, Newstead S. (2018) Structural basis for amino acid transport by the CAT family of SLC7 transporters. Nature Communications

Parker JL, Newstead S. (2017) Structural basis of nucleotide sugar transport across the Golgi membrane. Nature

Parker JL, Li C, Brinth A, Wang Z, Vogeley L, Solcan N, Ledderboge-Vucinic G, Swanson JMJ, Caffrey M, Voth GA, Newstead S. (2017) Proton movement and coupling in the POT family of peptide transporters. PNAS.

Newstead S. (2017) Recent advances in understanding proton coupled peptide transport via the POT family. Curr. Opin. Struct. Biol.

Newstead S. (2017) Symmetry and Structure in the POT Family of Proton Coupled Peptide Transporters. Symmetry.

Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R, Siebold, C. (2016) Structural basis of Smoothened regulation by its extracellular domains. Nature

Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. (2016) Engineering vanilloid-sensitivity into the rat TRPV2 channel. eLife

Samsudin F, Parker JL, Sansom MS, Newstead S, Fowler PW. (2016) Accurate prediction of ligand affinities for a peptide transporter. Cell Chemistry & Biology.

Parker JL, Newstead S. (2016) Membrane Protein Crystallisation: Current Trends and Future Perspectives. Adv. Exp. Med. Biol.