October 11th 2019: How lipids regulate nucleotide sugar transporters and much more! Research by Jo Parker and Robin Corey reveal how a fungal nucleotide sugar transporter functions in the lipid bilayer. A great collaboration with the Stansfeld group.
Online now in Nature Communications.
October 1st 2019: How protons control structural transitions in an amino acid transporter. Research by Wellcome DPhil student Zhiyi Wu reveals how a key glutamate residue regulates transport in a bacterial homologue of the SLC36 family mammalian amino acid transporters. A great collaboration with the Biggin group.
Online now in Biophysical journal.
June 3rd 2019: Insights into L-type heteromeric amino acid transporters.
Two recent cryo-EM structures of the human L-type heteromeric amino acid transporter LAT1–CD98hc reveal surprising new insights into both amino acid transport in the human body and the roles of CD98hc as a cell-surface antigen and trafficking chaperone. Read my News and Views piece in NSMB.
April 16th 2019: Gateway to the Golgi.
Hot off the press, our latest review on Nucleotide Sugar Transporters, the Gateway to the Golgi, out now in Current Opinion in Structural Biology.
March 8th 2019: Following a great collaboration with the Barr and Seeger groups, our latest paper ‘Structural basis for pH dependent retrieval of ER proteins from the Golgi by the KDEL receptor‘ is out now in Science. Well done everyone and enjoy the movie!
January 2nd 2019: Our work on the ‘Structural basis for prodrug recognition by the SLC15 family of peptide transporters‘ is now online in PNAS.
November 14th 2018: Congratulations to Ashley for a successful defense of his thesis ‘Structural and Biophysical Characterisation of Marine Viruses and Amino Acid Transporters, completed jointly in the Huiskonen and Newstead groups.
October 26th 2018: ‘Structural basis for prodrug recognition by the SLC15 family of peptide transporters‘ – out now on BioRxiv!
July 3rd 2018: The molecular basis for BO production in the human axilla revealed through collaboration with Gavin Thomas and Unilever Discover. Latest paper in eLIFE out now.. and featured on the BBC health web site!
April 3rd 2018: Paper with collaborator Randy Stockbridge on the fluoride channel; Cork in bottle occlusion as a mechanism for monobody block of channel function.
February 7th 2018: Structure and mechanism of amino acid transport in the SLC7 family, out now in Nature Communications.
December 6th 2017: Congratulations to Katharina for a successful defense of her thesis ‘Structural studies on cationic amino acid transporters’.
December 2017: Publication of our research on the role of water wires as proton shuttles in the binding site of POT family peptide transporters. Link here.
November 2017: Publication of the crystal structure of the nucleotide sugar transporter in Nature! Link here.