Review articles are available here.
A complete list of publications is available on PubMed.
2016-2025
Middleton AJ & Markússon S, et al. (2025) SLC45A4 is a pain gene encoding a neuronal polyamine transporter. Nature.
Parker JL, Deme JC, Feddersen B, Lea SM, Newstead S. (2025) Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi. Res Sq [preprint].
Rödström KEJ, Eymsh B, Proks P, Hayre MS, Cordeiro S, Mendez-Otalvaro E, Mandry C, Rowland A, Kopec W, Newstead S, Baukrowitz T, Schewe M, Tucker SJ (2025) Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics.Nature Structural & Molecular Biology.
Hall PR, Jouen-Tachoire T, Schewe M, Baukrowitz T, Carptener EP, Newstead S, Rödström KEJ, Tucker SJ (2025) Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in diease. Structure.
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S (2024) Structural basis for antibiotic transport and inhibition in PepT2. Nature Communications.
Lichtinger SM, Parker JL, Newstead S, Biggin PC (2024) The mechanism of mammalian proton-coupled peptide transporters. Elife.
Rödström KEJ, Cloake A, Sörmann J, Baronina A, Smith KHM, Pike ACW, Ang J, Proks P, Schewe M, Holland-Kaye I, Bushell SR, Elliott J, Pardon E, Baukrowitz T, Owens RJ, Newstead S, Steyaert J, Carpenter EP, Tucker SJ (2024) Extracellular modulation of TREK-2 activity with nanobodies provides insights into the mechanism of K2P channel regulation. Nature Communications.
Wu Z, Smith K, Gerondopoulos A, Sobajima T, Parker JL, Barr FA, Newstead S, Biggin PC (2024) Molecular basis for pH sensing in the KDEL trafficking receptor. Structure.
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S. (2023) Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nature Structural & Molecular Biology.
Loebel M, Salphati, SP, El Omari K, Wagner A, Tucker SJ, Parker JL, Newstead S. (2022) Structural basis for proton coupled cystine transport by cystinosin. Nature Communications.
Fiore A, Zeitler L, Russier M, Groß A, Hiller MK, Parker JL, Stier L, Köcher T, Newstead S, Murray PJ. (2022) Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling. Mol Cell.
Parker JL, Deme JC, Wu Z, Kuteyi G, Huo J, Owens RJ, Biggin PC, Lea SM, Newstead S. (2021) Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. SciAdv
Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S. (2021) Molecular basis for redox control by the human cystine/glutamate antiporter System xc–. Nature Communications
Adams O, Deme JC, Parker JL, the CRyPTIC Consortium, Fowler PW., Lea SM, Newstead S. (2021) Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target. Structure.
Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, David Goldman I, Owens R.J, Biggin PC, Lea SM, Newstead S. (2021) Structural basis of antifolate recognition and transport by PCFT. Nature.
Gerondopoulos A, Bräuer P, Sobajima T, Wu Z, Parker JL, Biggin PC, Barr FA, Newstead S. (2021) A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval. Elife.
Wu Z, Newstead S, Biggin PC. (2020) The KDEL trafficking receptor exploits pH to tune the strength of an unusal short hydrogen bond. Sci Rep.
van Dijk FS, et al. (2020) Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2. Am J Hum Genet.
Zimmermann I, Egloff P, Hutter CAJ, Kuhn BT, Bräuer P, Newstead S, Dawson RJP, Geertsama ER, Seeger MA. (2020) Generation of synthetic nanobodies against delicate proteins. Nat Protoc.
Parker JL, Corey R, Stansfeld P, Newstead S. (2019) Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer. Nature Communications.
Zhiyi W, Alibay I, Newstead S, Biggin PC. (2019) Proton control transitions in an amino acid transporters. Biophysical Journal.
Bräuer P, Parker JL, Gerondopoulos A, Zimmermann I, Seeger MA, Barr FA, Newstead S. (2019) Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor. Science
Minhas GS, Newstead S. (2019) Structural basis for prodrug recognition by the SLC15 family of proton coupled peptide transporters. PNAS.
Minhas GS, Bawdon D, Herman R, Rudden M, Stone AP, James AG, Thomas GH, Newstead S. (2018) Structural basis of malodour precursor transport in the human axilla. eLIFE
McIlwain BC, Newstead S, Stockbridge RB. (2018) Cork-in-Bottle Occlusion of Fluoride Ion Channels by Crystallization Chaperones. Structure
Jungnickel, EJK, Parker JL, Newstead S. (2018) Structural basis for amino acid transport by the CAT family of SLC7 transporters. Nature Communications
Parker JL, Newstead S. (2017) Structural basis of nucleotide sugar transport across the Golgi membrane. Nature
Parker JL, Li C, Brinth A, Wang Z, Vogeley L, Solcan N, Ledderboge-Vucinic G, Swanson JMJ, Caffrey M, Voth GA, Newstead S. (2017) Proton movement and coupling in the POT family of peptide transporters. PNAS.
Newstead S. (2017) Recent advances in understanding proton coupled peptide transport via the POT family. Curr. Opin. Struct. Biol.
Newstead S. (2017) Symmetry and Structure in the POT Family of Proton Coupled Peptide Transporters. Symmetry.
Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R, Siebold, C. (2016) Structural basis of Smoothened regulation by its extracellular domains. Nature
Zhang F, Hanson SM, Jara-Oseguera A, Krepkiy D, Bae C, Pearce LV, Blumberg PM, Newstead S, Swartz KJ. (2016) Engineering vanilloid-sensitivity into the rat TRPV2 channel. eLife
Samsudin F, Parker JL, Sansom MS, Newstead S, Fowler PW. (2016) Accurate prediction of ligand affinities for a peptide transporter. Cell Chemistry & Biology.
Parker JL, Newstead S. (2016) Membrane Protein Crystallisation: Current Trends and Future Perspectives. Adv. Exp. Med. Biol.