PepT2 ECD

In this study we presented the crystal structure of the extracellular domain from both PepT1 and PepT2. These structures revealed two immunoglobulin-like folds connected in tandem. Functional and biophysical studies demonstrated these domains interact with the intestinal protease trypsin, suggesting a role in clustering proteolytic activity to the site of peptide transport in eukaryotic cells. Structure 2015

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