April 8th 2020: Detailed protocol released for generating synthetic nanobodies (sybodies) against your favourate membrane protein! Out in Nature Protocols.
March 27th 2020: Update on recent progress in understanding prodrug transport by the SLC15 family of peptide transports. Online now in Biochem Soc Trans.
October 11th 2019: How lipids regulate nucleotide sugar transporters and much more! Research by Jo Parker and Robin Corey reveal how a fungal nucleotide sugar transporter functions in the lipid bilayer. Online now in Nature Communications.
October 1st 2019: How protons control structural transitions in an amino acid transporter. Research by Wellcome DPhil student Zhiyi Wu reveals how a key glutamate residue regulates transport in a bacterial homologue of the SLC36 family mammalian amino acid transporters. Online now in Biophysical journal.
June 3rd 2019: Insights into L-type heteromeric amino acid transporters.
Two recent cryo-EM structures of the human L-type heteromeric amino acid transporter LAT1–CD98hc reveal surprising new insights into both amino acid transport in the human body and the roles of CD98hc as a cell-surface antigen and trafficking chaperone. Read my News and Views piece in NSMB.
April 16th, 2019. Gateway to the Golgi; How nucleotide sugar transporters shuttle molecules across the Golgi membrane.
March 8th 2019: Following a great collaboration with the Barr and Seeger groups, our latest paper ‘Structural basis for pH dependent retrieval of ER proteins from the Golgi by the KDEL receptor‘ is out in Science.